ABSTRACT
Polymorphism in solids is a common phenomenon in drugs, which can lead to compromised quality due to changes in their physicochemical properties, particularly solubility, and, therefore, reduce bioavailability. Herein, a bibliographic survey was performed based on key issues and studies related to polymorphism in active pharmaceutical ingredient (APIs) present in medications from the Farmácia Popular Rede Própria. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Few mandatory tests for the identification and control of polymorphism in medications are currently available, which can result in serious public health concerns.
O polimorfismo em sólidos é um fenômeno frequente em fármacos e pode levar a problemas na qualidade dos medicamentos por alterar suas propriedades físico-químicas, em especial a solubilidade e, consequentemente, a biodisponibilidade. Nesse trabalho realizou-se levantamento bibliográfico sobre os principais estudos e problemas relacionados ao polimorfismo em fármacos presentes nos medicamentos disponibilizados pela Farmácia Popular do Brasil. O polimorfismo deve ser controlado a fim de evitar possível ineficácia terapêutica e/ou dosagem inapropriada dos medicamentos. Destacamos que são poucos os ensaios obrigatórios para identificação e controle desse fenômeno em medicamentos, o que pode acarretar grande problema de saúde pública.
Subject(s)
Solubility/drug effects , Community Pharmacy Services , Quality Control , Review Literature as Topic , Production of ProductsABSTRACT
ABSTRACT: In general, the brachial artery divides into the radial and ulnar arteries at the level of the cubital fossa (elbow), just proximal to or right over the cubital anastomosis and these arteries are the main responsible for the irrigation of the forearm. After revising an extensive bibliographical literature, we found out that only few authors admit that divisions can appear below the cubital fossa (low division) and at the upper, middle or lower third of the arm (high divisions), but these are considered rare events. While dissecting one male cadaver on an ordinary practical class in the Laboratory of Gross Anatomy, we observed a high division of the brachial artery, located at the level of the superior part of the upper third in both arms, close to the axilla. We decided to report this anatomical variation because a bilateral event such as that is rarer yet.